Squeezing the Sweet Bejesus Outta Me PC

[Benny2guns]

So simple answer is; Some are very safe and some do take into consideration the chip sets.

I just get nervous with the idea of putting water inside a case full of electrical pieces and parts. But its not my PC so why not

No, short answer is the only reason you need to use liquid cooling is if you are going to get into extreme overclocking.
In the above case, nothing is safe when you are overclocking, any overclocker will tell you the same.